The debate about what causes autism continues, with two new studies suggesting there might be more of an environmental component at play than previously thought.
The first, published online Monday in the suggests that at least half of what the authors call "liability to autism" might be explained by environmental factors.
Researchers considered more than 50 sets of identical twins and 130 sets of fraternal twins, in which at least one child had a diagnosis of strict autism or Autism Spectrum Disorder (ASD). Relying on both parental reports and direct observation, they then used existing twin models, which rely on the degrees of shared genetics among fraternal and identical twins to determine how much certain factors are associated with autism risk. They found that only 40 percent of the risk of autism development was owed to genetic heritability, while 55 percent was linked to environmental factors. "These two studies are interesting because they're kind of a paradigm shifter in finding there is a much lower genetic contribution [to autism and ASD development]," said
Lisa Croen, PhD, director of the Kaiser Permanente Autism Research Program and the second study's lead author. "There is a much larger environmental component at play here than has been understood up to this point," she added. Croen was also an author on the twin pairs study.
The first, published online Monday in the suggests that at least half of what the authors call "liability to autism" might be explained by environmental factors.
Researchers considered more than 50 sets of identical twins and 130 sets of fraternal twins, in which at least one child had a diagnosis of strict autism or Autism Spectrum Disorder (ASD). Relying on both parental reports and direct observation, they then used existing twin models, which rely on the degrees of shared genetics among fraternal and identical twins to determine how much certain factors are associated with autism risk. They found that only 40 percent of the risk of autism development was owed to genetic heritability, while 55 percent was linked to environmental factors. "These two studies are interesting because they're kind of a paradigm shifter in finding there is a much lower genetic contribution [to autism and ASD development]," said
Lisa Croen, PhD, director of the Kaiser Permanente Autism Research Program and the second study's lead author. "There is a much larger environmental component at play here than has been understood up to this point," she added. Croen was also an author on the twin pairs study.
No comments:
Post a Comment